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abnormalities ( Patergnani et al. 2021 ). Muscle dysfunctions related to pathological conditions affect health status. In many subjects, skeletal muscle dysfunction may evolve into sarcopenia or cachexia, both of which are connected with increased morbidity
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homeostasis including the regulation of the vascular tone, blood flow and vessel vasodilation. NO may diffuse to adjacent cells to promote smooth muscle cell (SMC) relaxation and inhibit their proliferation ( Fig. 1 ). NO and NO-derived species such as S
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deletion of Sod1 in adult mice resulted in accelerated atrophy and contractile dysfunction of skeletal muscle as well as a disruption of NMJ morphology in older mice ( Bhaskaran et al. 2020 ). Lessons from genetic manipulation of ROS control
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synthesis in T2DM (Bianchi& Volpato 2016). These morphological changes in muscle fiber are also associated with functional impairments in skeletal muscle, as demonstrated by muscle weakness and motor dysfunction ( Punkt et al. 1999 , Bianchi & Volpato 2016
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in particular the muscle dysfunction so frequent in the elderly. The emerging use of natural phenolic compounds as a promising approach to extending lifespan by modulating metabolic pathways involved in aging has been reviewed ( Spagnuolo et al
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Department of Physiology, University of Valencia, Valencia, Spain
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CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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Department of Physiology, University of Valencia, Valencia, Spain
CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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mitochondrial dysfunction and insulin resistance in skeletal muscle . Molecular and Cellular Biology 32 309 – 319 . ( https://doi.org/10.1128/MCB.05603-11 ) Ji W Chen X Lv J Wang M Ren S Yuan B Wang B Chen L 2014 Liraglutide exerts
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
CIBERehd, University of Valencia, Valencia, Spain
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, mitochondrial dysfunction, and tissue damage. Mitochondrial dysfunction is also linked to insulin resistance (IR) and impaired glucose uptake in target tissues, including adipose tissue, skeletal muscle and liver ( Petersen et al. 2003 ). Furthermore
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Introduction Among age-related diseases, sarcopenia is defined as a combination of low muscle mass with low muscle function ( Bautmans et al. 2009 , Tournadre et al. 2019 , Kim et al. 2021 ). This disabling disease, which mainly occurs
Division of Cardiology, Department of Medical Sciences, University of Turin, Italy
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calcium homeostasis with ensuing cardiac muscle cell dysfunction ( Sartiani et al. 2016 ). The involvement of NADPH enzyme, as another main source of ROS, was demonstrated in human neutrophils showing an oxidative burst following the treatment with
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to counteract sepsis ( Beltrán-García et al. 2022 ), in the dysfunction of endothelial nitric oxide synthase occurring in vascular diseases ( Negre-Salvayre et al. 2022 ), in liver regeneration ( Bellanti et al. 2022 ), in the complex
