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diseases. If left untreated, it can lead to acquired immune deficiency syndrome (AIDS) which is characterized, as its name indicates, by a deficiency of the immune system, which predisposes the patients to the development of certain cancers, infections, or
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. Nature Medicine 6 422 – 428 . ( https://doi.org/10.1038/74680 ) Ozen M Zhao H Lewis DB Wong RJ & Stevenson DK 2015 Heme oxygenase and the immune system in normal and pathological pregnancies . Frontiers in Pharmacology 6 84. ( https
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by the immune system triggering the onset of both cellular and humoral immune responses ( Thiele et al. 2008 , Papac-Milicevic et al. 2016 ). These antigens, also called oxidative stress-derived epitopes (OSEs), are presently implicated in the
Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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( Rudd et al. 2020 , Beltrán-García et al. 2022 ). Clinically, sepsis is characterized by a simultaneous hyperinflammatory and anti-inflammatory response, which contribute to the deregulation of the patient’s immune system ( Nakamori et al. 2020
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Department of Environmental Toxicology, University of California, Davis, California, USA
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the protection against infections ( Chávez et al. 2009 ). In humans, deleterious variants of the DUOX2 gene are associated with altered microbiota-immune system homeostasis and increased IBD risk ( Grasberger et al. 2021 ). Thus, the importance
Laboratory of Comparative Neurobiology, Cavanilles Institute of Biodiversity and Evolutionary Biology, University of Valencia, Valencia, Spain
INSERM UMR1141, Université Paris Diderot, Sorbonne Paris Cité, Paris, France
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Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain
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Department of Physiology, University of Valencia, Burjassot, Spain
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stress, were identified in cells of the innate immune system. In this study, a genetic signature was defined which produces oxidative injury and neurotoxicity that have been identified in neuroinflammatory diseases. This finding is very relevant as they
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-protein system not only regulates the intestinal cell polarization and the flux of small solutes and bigger molecules from the apical to the basolateral membrane of the cell, but it also modulates intracellular signalling of the immune and inflammatory responses
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role in the removal of reactive oxygen species (ROS) and redox regulation. Selenoproteins are also a key factor in the antioxidant system ( Conrad et al. 2018 , Dagnell et al. 2018 ). Although selenium is an essential element, it is highly toxic
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the nucleus, thioredoxins facilitate DNA binding to NF-κB, while they block the deterioration of IκB and inhibit NF-κB activation in the cytoplasm ( Hirota et al. 1999 ). In the immune system, among the antioxidant genes, the nuclear factor erythroid
PULSALYS SATT Lyon-Saint Etienne, Villeurbanne, France
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antioxidants provided by food nutrients ( Maleki et al. 2019 ). Some clinical studies demonstrated the benefits of a diet rich in antioxidants to prevent oxidative stress and various related diseases, as well as supporting the immune system ( Willett 2006
