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Francesco Bellanti Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

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Gianluigi Vendemiale Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

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Gaetano Serviddio Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy

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is impaired by loss of β1-integrin or p21 overexpression, cholangiocytes may behave as facultative progenitors to contribute to hepatocellular regeneration ( Raven et al. 2017 ). Evidence from a model of toxic liver injury suggests that p21

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