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Ebenezer Tunde Olayinka Biochemistry unit, Department of Chemical Sciences, Ajayi Crowther University, Oyo, Nigeria

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Toluwalase Oreofe Oni Biochemistry unit, Department of Chemical Sciences, Ajayi Crowther University, Oyo, Nigeria

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Abosede Temitope Olajide Biochemistry unit, Department of Chemical Sciences, Ajayi Crowther University, Oyo, Nigeria

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Babajide Oluwaseun Ajayi Biochemistry unit, Department of Chemical Sciences, Ajayi Crowther University, Oyo, Nigeria

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Samuel Abiodun Kehinde Biochemistry unit, Department of Chemical Sciences, Ajayi Crowther University, Oyo, Nigeria
Department of Environmental Health Science, Ajayi Crowther University, Oyo, Nigeria

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membrane's outer side ( Jovetic et al. 2010 ). TEIC has been known to cause a number of toxicities such as nephrotoxicity and neurotoxicity among others and adverse effects in experimental animals and humans. Some of its reported toxicity in animal models

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Irene Martín-Bocanegra Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain

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Thaissa Horne Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain

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Belén Maqueda-Hernández Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain

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Elena Navarro-Villarán Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain
Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain

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Jordi Muntané Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain
Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain
Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Madrid, Spain

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-dependent increases in the production of hydrogen peroxide by glioma cells ( Jin et al. 2008 ). However, the major side effect of FK506 vs mTORC1 inhibitors is its nephrotoxicity ( Navarro-Villaran et al. 2016 ), which is also associated with the induction of

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Elena Cavallone Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy
Division of Cardiology, Department of Medical Sciences, University of Turin, Italy

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Amir Hassan Mousavi Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy

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Carloalberto Biolé Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy

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Giulia Nangeroni Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy

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Alessandra Chinaglia Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy

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Matteo Bianco Division of Cardiology, San Luigi Gonzaga University Hospital, Orbassano, Turin, Italy

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anti-inflammatory drug, it carries gastrointestinal side effects and nephrotoxic properties, limiting its chronic administration in the elderly population ( Berk et al. 2013 ). Patisiran Patisiran is a siRNA molecule, administered

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Daniel Rafferty Midwestern University Chicago, College of Osteopathic Medicine, Downers Grove, Illinois, USA

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Luana Martins de Carvalho Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA

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Mason Sutter Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA

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Katlyn Heneghan Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

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Victoria Nelson Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

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Megan Leitner Midwestern University Chicago, College of Osteopathic Medicine, Downers Grove, Illinois, USA

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Charlotte Bolch Office of Research and Sponsored Programs, Midwestern University, Glendale, Arizona, USA

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Amy W Lasek Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA

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Prasanth Puthanveetil Midwestern University Chicago, College of Osteopathic Medicine, Downers Grove, Illinois, USA
Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

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and strokes . Alcohol 1 325 – 331 . ( https://doi.org/10.1016/0741-8329(8490056-9 ) Appenroth D Schulz O & Winnefeld K 1996 Riboflavin can decrease the nephrotoxic effect of chromate in young and adult rats . Toxicology Letters 87 47 – 52

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