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membrane's outer side ( Jovetic et al. 2010 ). TEIC has been known to cause a number of toxicities such as nephrotoxicity and neurotoxicity among others and adverse effects in experimental animals and humans. Some of its reported toxicity in animal models
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-dependent increases in the production of hydrogen peroxide by glioma cells ( Jin et al. 2008 ). However, the major side effect of FK506 vs mTORC1 inhibitors is its nephrotoxicity ( Navarro-Villaran et al. 2016 ), which is also associated with the induction of
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anti-inflammatory drug, it carries gastrointestinal side effects and nephrotoxic properties, limiting its chronic administration in the elderly population ( Berk et al. 2013 ). Patisiran Patisiran is a siRNA molecule, administered
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and strokes . Alcohol 1 325 – 331 . ( https://doi.org/10.1016/0741-8329(8490056-9 ) Appenroth D Schulz O & Winnefeld K 1996 Riboflavin can decrease the nephrotoxic effect of chromate in young and adult rats . Toxicology Letters 87 47 – 52