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Jesús Beltrán-García
Jesús Beltrán-García
Center for Biomedical Research Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Valencia, Spain
Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Rebeca Osca-Verdegal
Rebeca Osca-Verdegal
Center for Biomedical Research Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Valencia, Spain
Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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José Luis García-Giménez
José Luis García-Giménez
Center for Biomedical Research Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Valencia, Spain
Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Federico V. Pallardó
Federico V. Pallardó
Center for Biomedical Research Network on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Valencia, Spain
Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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). Nonetheless, despite the increasing evidence of the role that oxidative stress is playing in sepsis, the implications of oxidative stress in the activation of pyroptosis have been little explored in sepsis. Figure 1 Scheme of NLRP3 inflammasome assembly
Valeria Cordone
Valeria Cordone
Department of Environment and Prevention, University of Ferrara, Ferrara, Italy
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Alessandra Pecorelli
Alessandra Pecorelli
Animal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis Research Campus, Kannapolis, North Carolina, USA
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Giuseppe Valacchi
Giuseppe Valacchi
Department of Environment and Prevention, University of Ferrara, Ferrara, Italy
Animal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis Research Campus, Kannapolis, North Carolina, USA
Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
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Animal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis Research Campus, Kannapolis, North Carolina, USA
Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
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). Other studies on both primary fibroblasts and PBMCs evidenced a deregulated NLRP3 inflammasome response ( Pecorelli et al. 2020 b , Cordone et al. 2022 ), an intracellular multi-protein complex assembled in response to different stimuli (both
Salvatore Sutti
Salvatore Sutti
Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University of East Piedmont, Novara, Italy
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Emanuele Albano
Emanuele Albano
Department of Health Sciences and Interdisciplinary Research Centre for Autoimmune Diseases, University of East Piedmont, Novara, Italy
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response involve the stimulation of inflammasome ( Szabo & Petrasek 2015 ) and gut dysbiosis associated with obesity ( Aron-Wisnewsky et al. 2020 ). This latter can contribute to hepatic inflammation through changes in the enteral adsorption of bacterial
Aranzazu M de Marañón
Aranzazu M de Marañón
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
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Susana Rovira-Llopis
Susana Rovira-Llopis
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, Valencia, Spain
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Department of Physiology, University of Valencia, Valencia, Spain
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Milagros Rocha
Milagros Rocha
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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Víctor M Víctor
Víctor M Víctor
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, Valencia, Spain
CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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Department of Physiology, University of Valencia, Valencia, Spain
CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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mitoTEMPO, few reviews have assessed its beneficial effect on different complications of T2D. This molecule reduces mtROS production and the activation of the NLR-family pyrin domain containing 3 inflammasome, and the subsequent production of cytokine
Jeongin Son
Jeongin Son
The Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park PA, USA
Department of Discovery Protein Science, Amgen Inc., South San Francisco, California, USA
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Department of Discovery Protein Science, Amgen Inc., South San Francisco, California, USA
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Jacob T Bailey
Jacob T Bailey
The Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park PA, USA
Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
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Department of Immunology and Microbial Disease, Albany Medical College, Albany, New York, USA
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Stephen Worrell
Stephen Worrell
The Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park PA, USA
University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
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Adam B Glick
Adam B Glick
The Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park PA, USA
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. Molecular and Cellular Biology 23 7198 – 7209 . ( https://doi.org/10.1128/MCB.23.20.7198-7209.2003 ) Davis BK Wen H & Ting JPY 2011 The inflammasome NLRs in immunity, inflammation, and associated diseases . Annual Review of Immunology 29 707 – 735
Carlo Cervellati
Carlo Cervellati
Department of Translational Medicine and for Romagna, University of Ferrara, Via Luigi Borsari, Ferrara, Italy
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Paolo Casolari
Paolo Casolari
Interdepartmmental Study Center for Inflammatory and Smoke-Related Airway Diseases, Cardiorespiratory and Internal Medicine Section, University of Ferrara, Ferrara, Italy
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Alessandra Pecorelli
Alessandra Pecorelli
Department of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari, Ferrara, Italy
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Claudia Sticozzi
Claudia Sticozzi
Department of Life Sciences, University of Siena, Via Aldo Moro, Siena, Italy
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Francesco Nucera
Francesco Nucera
Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy
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Alberto Papi
Alberto Papi
Interdepartmmental Study Center for Inflammatory and Smoke-Related Airway Diseases, Cardiorespiratory and Internal Medicine Section, University of Ferrara, Ferrara, Italy
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Gaetano Caramori
Gaetano Caramori
Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy
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Giuseppe Valacchi
Giuseppe Valacchi
Department of Environmental and Prevention Sciences, University of Ferrara, Via Luigi Borsari, Ferrara, Italy
Department of Animal Science, Plants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina, USA
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
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Department of Animal Science, Plants for Human Health Institute, North Carolina State University, Kannapolis, North Carolina, USA
Department of Food and Nutrition, Kyung Hee University, Seoul, Korea
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E Guiotto A Vallese A Cervellati F & Valacchi G 2022 Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation . Redox Biology 56 102440 . ( https://doi.org/10.1016/j.redox.2022.102440 ) Gillard
Noemi Iaia
Noemi Iaia
Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano (Turin), Italy
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Federico Canzoneri
Federico Canzoneri
Soremartec Italia Srl, Ferrero Group, Alba, Italy
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Ginevra Rosso
Ginevra Rosso
Soremartec Italia Srl, Ferrero Group, Alba, Italy
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Roberto Menta
Roberto Menta
Soremartec Italia Srl, Ferrero Group, Alba, Italy
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Fiorella Biasi
Fiorella Biasi
Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospital, Orbassano (Turin), Italy
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-brain axis: how microbiota and host inflammasome influence brain physiology and pathology . Frontiers in Immunology 11 604179. ( https://doi.org/10.3389/fimmu.2020.604179 ) Serra G Incani A Serreli G Porru L Melis MP Tuberoso CIG Rossin D
Mariapaola Nitti
Mariapaola Nitti
Department of Experimental Medicine, University of Genoa, Italy
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Jasmin Ortolan
Jasmin Ortolan
Department of Experimental Medicine, University of Genoa, Italy
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Anna Lisa Furfaro
Anna Lisa Furfaro
Department of Experimental Medicine, University of Genoa, Italy
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activation and secretion of pro-inflammatory cytokines IL-1β and IL-18, acting as inflammasome inhibitors ( Kim & Lee 2013 ). However, the anti-inflammatory activity of HO-1 is mediated not only by CO but also by bilirubin. Indeed, the potent anti
Cristina Mas-Bargues
Cristina Mas-Bargues
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, Spain
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Consuelo Borrás
Consuelo Borrás
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, Spain
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José Viña
José Viña
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable-Instituto de Salud Carlos III (CIBERFES-ISCIII), INCLIVA, Valencia, Spain
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cell response, inhibits the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway, and inhibits viral replication ( Poe & Corn 2020 ). However, a double-blind randomized clinical trial using high doses of NAC in SARS-CoV-2-infected patients
Teresa Vezza
Teresa Vezza
Servicio de Digestivo, Hospital Universitario Virgen de las Nieves, Granada, Spain
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Clara Luna-Marco
Clara Luna-Marco
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Susana Rovira-Llopis
Susana Rovira-Llopis
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Víctor M Víctor
Víctor M Víctor
Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
CIBERehd, University of Valencia, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
CIBERehd, University of Valencia, Valencia, Spain
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atherosclerosis . Circulation Research 130 831 – 847 . ( https://doi.org/10.1161/CIRCRESAHA.121.320047 ) Rocha M Apostolova N Diaz-Rua R Muntane J & Victor VM 2020 Mitochondria and T2D: Role of Autophagy, ER Stress, and Inflammasome . Trends in
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