Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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Biomedical Research Institute INCLIVA, Valencia, Spain
Department of Physiology, Medicine and Dentistry School, University of Valencia, Valencia, Spain
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). Nonetheless, despite the increasing evidence of the role that oxidative stress is playing in sepsis, the implications of oxidative stress in the activation of pyroptosis have been little explored in sepsis. Figure 1 Scheme of NLRP3 inflammasome assembly
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Animal Science Department, Plants for Human Health Institute, North Carolina State University, Kannapolis Research Campus, Kannapolis, North Carolina, USA
Department of Food and Nutrition, Kyung Hee University, Seoul, South Korea
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). Other studies on both primary fibroblasts and PBMCs evidenced a deregulated NLRP3 inflammasome response ( Pecorelli et al. 2020 b , Cordone et al. 2022 ), an intracellular multi-protein complex assembled in response to different stimuli (both
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2022 Oxidative stress leads to severe phenotypes in sepsis through activation of NLRP3-pyroptosis . Redox Experimental Medicine 2022 1. ( https://doi.org/10.1530/REM-22-0006 ) Cordone V Pecroelli A Valacchi G 2022 Sirtuins as potential
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interleukin-1β ( Szabo & Petrasek 2015 ). In detail, NASH associates with specific activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome and NLRP3 blockade or interference with caspase 1 reduces liver inflammation and fibrosis in experimental
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Department of Physiology, University of Valencia, Valencia, Spain
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CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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Department of Physiology, University of Valencia, Valencia, Spain
CIBERehd – Department of Pharmacology, University of Valencia, Valencia, Spain
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G Yoshida T & Noguchi M 2005 Heme oxygenase and heme degradation . Biochemical and Biophysical Research Communications 338 558 – 567 . ( https://doi.org/10.1016/j.bbrc.2005.08.020 ) Kim SJ & Lee SM 2013 NLRP3 inflammasome activation in
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cell response, inhibits the NLR family pyrin domain containing 3 (NLRP3) inflammasome pathway, and inhibits viral replication ( Poe & Corn 2020 ). However, a double-blind randomized clinical trial using high doses of NAC in SARS-CoV-2-infected patients
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). DJ-1 negatively regulates NLRP3 inflammasome activation via upregulated Nrf2/Trx1 axis, resulting in controlled microglia-mediated neuroinflammation in PD mice ( Ji et al. 2020 ). Induced T cell activation and differentiation are hallmarks of
