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Malcolm J Jackson MRC-Versus Arthritis Centre for Integrative Research into Musculoskeletal Ageing (CIMA), Department of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, UK

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muscle atrophy, NMJ degeneration and muscle weakness phenotypes that occur in the Sod1KO mice, suggesting that the redox balance in motor neurons was a critical mediator of muscle innervation and atrophy ( Sakellariou et al. 2014 ). To address the

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Cristina Russo Section of Pathology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

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Maria Stella Valle Section of Physiology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

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Lucia Malaguarnera Section of Pathology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

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impinges negatively on a wide array of biological molecules and gene expression in cells. Usually, when oxidative stress occurs, compensatory antioxidant activity is established in order to restore redox balance ( Dalton et al. 1999 ). ROS are engaged in

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