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Ludovica Spagnuolo Research Unit of Food and Nutritional Sciences, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Rome, Italy

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Diana Lelli Unità Operativa di Ricerca di Geriatria, Fondazione Policlinico Campus Bio-Medico di Roma

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Greta Lattanzi Research Unit of Food and Nutritional Sciences, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Rome, Italy

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Laura Dugo Research Unit of Food and Nutritional Sciences, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Rome, Italy
NBFC, National Biodiversity Future Center, Palermo, Italy

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Claudio Pedone Unità Operativa di Ricerca di Geriatria, Fondazione Policlinico Campus Bio-Medico di Roma
Unità di Ricerca di Geriatria, Facoltà Dipartimentale di Medicina e Chirurgia. Università Campus Bio-Medico di Roma

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Laura De Gara Research Unit of Food and Nutritional Sciences, Department of Science and Technology for Sustainable Development and One Health, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, Rome, Italy
NBFC, National Biodiversity Future Center, Palermo, Italy

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activate AMPK and suppress mTOR signaling pathways, as documented in an ischemia-induced cardiomyocyte injury model ( Yang et al. 2013 ) and also in other models, such as oxidative stress-induced intestinal barrier injury ( Cao et al. 2020 ). Finally

Article Type:
Review Article
Collections:
Effects of anti-aging redox medicine
DOI:
https://doi.org/10.1530/REM-23-0017
Volume/Issue:
Volume 2023: Issue 1
Open access
Opeyemi S Ademowo Human Science Research Centre, University of Derby, Derby, UK

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Irundika H K Dias Aston Medical School, Aston University, Aston Triangle, Birmingham, UK

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significant impact on the development of AD pathologies. Oxidative stress and oxidative modifications to macromolecules are one of the earliest events in AD pathology ( Nunomura et al. 2001 , Bai et al. 2022 ). Among the lipid oxidation observed in AD

Article Type:
Review Article
DOI:
https://doi.org/10.1530/REM-22-0009
Volume/Issue:
Volume 2022: Issue 1
Open access
Daniel Rafferty Midwestern University Chicago, College of Osteopathic Medicine, Downers Grove, Illinois, USA

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Luana Martins de Carvalho Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA

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Mason Sutter Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA

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Katlyn Heneghan Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

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Victoria Nelson Department of Biomedical Sciences, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

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Megan Leitner Midwestern University Chicago, College of Osteopathic Medicine, Downers Grove, Illinois, USA

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Charlotte Bolch Office of Research and Sponsored Programs, Midwestern University, Glendale, Arizona, USA

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Amy W Lasek Department of Psychiatry, University of Illinois at Chicago, Chicago, Illinois, USA
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia, USA

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Prasanth Puthanveetil Midwestern University Chicago, College of Osteopathic Medicine, Downers Grove, Illinois, USA
Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

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product, adipic acid. Extensive lysine breakdown could lead to an increased formation of aminoadipic acid, which is also a marker for oxidative stress ( Fig. 9 ). Regarding tryptophan metabolism, hydroxytryptophan demonstrated a reduction, whereas

Article Type:
Research Article
DOI:
https://doi.org/10.1530/REM-23-0005
Volume/Issue:
Volume 2023: Issue 1
Open access
Roopak Murali Department of Human Genetics, Faculty of Biomedical Sciences, Technology and Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, India

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Rachel Evangelina Department of Human Genetics, Faculty of Biomedical Sciences, Technology and Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, India

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Joanna Pauline Samuel Department of Human Genetics, Faculty of Biomedical Sciences, Technology and Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, India

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Pooja Singh Department of Human Genetics, Faculty of Biomedical Sciences, Technology and Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, India

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Shivangi Saha Department of Plastic, Reconstructive and Burns Surgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India

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Maneesh Singhal Department of Plastic, Reconstructive and Burns Surgery, All India Institute of Medical Sciences (AIIMS), New Delhi, India

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Rajesh Kumar Gandhirajan Department of Human Genetics, Faculty of Biomedical Sciences, Technology and Research, Sri Ramachandra Institute of Higher Education and Research (SRIHER), Porur, Chennai, India

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humid environments. Humidity changes not only affect plasma jets but also generate free radicals such as OH − and H 2 O 2 , causing oxidative stress in biological samples ( Kirkpatrick et al. 2008 , Winter et al. 2013 ). Although several of these

Article Type:
Review Article
DOI:
https://doi.org/10.1530/REM-23-0026
Volume/Issue:
Volume 2024: Issue 1
Open access
Yumi Abiko Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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Akira Toriba Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

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Yoshito Kumagai Faculty of Medicine, University of Tsukuba, Ibaraki, Japan

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reactive compounds, which induce oxidative stress or electrophilic stress, to overcome their toxicity as Nrf2 comprehensively regulates proteins to reduce reactive oxygen species (ROS) and to facilitate the excretion of xenobiotics. Several lines of

Article Type:
Review Article
DOI:
https://doi.org/10.1530/REM-22-0021
Volume/Issue:
Volume 2023: Issue 1
Open access
Kota Saito Department of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka, Japan

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Yuta Matsuoka Center for Cancer Immunotherapy and Immunobiology, Graduate School of Medicine, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan

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Masami Abe Department of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka, Japan

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Nao Kato Department of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka, Japan

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Kazushi Morimoto Department of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka, Japan

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Ken-ichi Yamada Department of Molecular Pathobiology, Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi Higashi-ku, Fukuoka, Japan

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al. 2018 ). Conventionally, the ‘two-hit theory’ has been proposed as the molecular mechanism involved in NASH pathogenesis ( Day and James, 1998 ). This theory suggests that after steatosis, which is the ‘first hit’, oxidative stress promotes

Article Type:
Research Article
Collections:
Alteration of redox homeostasis and liver diseases
DOI:
https://doi.org/10.1530/REM-22-0024
Volume/Issue:
Volume 2023: Issue 1
Open access
Nahom Teferi Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Meron Challa University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Timothy Woodiwiss Department of Neurosurgery, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Bryan Allen Department of Radiation Oncology, Free Radical and Radiation biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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Michael Petronek Department of Radiation Oncology, Free Radical and Radiation biology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA

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the mitochondrial quality control pathway ( Ge et al. 2020 ). Under normal conditions, the PINK1 protein on the outer mitochondrial membrane is undetectable. During times of stress, such as impaired mitochondrial electron transport, oxidative stress

Article Type:
Review Article
DOI:
https://doi.org/10.1530/REM-23-0004
Volume/Issue:
Volume 2023: Issue 1
Open access
Daniela Weber Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
Food4Future (F4F), c/o Leibniz Institute of Vegetable and Ornamental Crops (IGZ), Grossbeeren, Germany
NutriAct Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany

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Tilman Grune Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany
Food4Future (F4F), c/o Leibniz Institute of Vegetable and Ornamental Crops (IGZ), Grossbeeren, Germany
NutriAct Competence Cluster Nutrition Research Berlin-Potsdam, Nuthetal, Germany
Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria

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oxidative stress ( Arunkumar et al. 2020 ). In addition to macula protection, carotenoid supplements have been shown to increase UV protection in human skin ( Ito et al. 2018 , Groten et al. 2019 , Baswan et al. 2020 ). Lutein and zeaxanthin are

Article Type:
Review Article
Collections:
Effects of anti-aging redox medicine
DOI:
https://doi.org/10.1530/REM-23-0019
Volume/Issue:
Volume 2023: Issue 1
Open access
Irene Martín-Bocanegra Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain

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Thaissa Horne Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain

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Belén Maqueda-Hernández Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain

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Elena Navarro-Villarán Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain
Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain

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Jordi Muntané Institute of Biomedicine of Seville (IBiS), Hospital University Virgen del Rocío/CSIC/University of Seville, Seville, Spain
Department of Medical Physiology and Biophysics, University of Seville, Seville, Spain
Biomedical Research Center for Hepatic and Digestive Diseases (CIBERehd), Madrid, Spain

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oxidative stress ( Yu et al. 2019 ). The impact of oxidative and nitrosative stress during the induction of cell death and cell cycle arrest by mTORC1 inhibitors ( Navarro-Villaran et al. 2020 ) is under investigation. Although rapamycin acutely

Article Type:
Review Article
DOI:
https://doi.org/10.1530/REM-23-0024
Volume/Issue:
Volume 2024: Issue 1
Open access
Maret G Traber Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA

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phospholipids and carotenoids in the macula ( Johra et al. 2020 ), thus reducing the oxidative stress burden in the eye. Due to the AREDS study design and the fact that vitamin E was part of the initial beneficial nutrient cocktail and therefore considered

Article Type:
Review Article
Collections:
Effects of anti-aging redox medicine
DOI:
https://doi.org/10.1530/REM-23-0020
Volume/Issue:
Volume 2023: Issue 1
Open access