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Cristina Russo Section of Pathology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

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Maria Stella Valle Section of Physiology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

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Lucia Malaguarnera Section of Pathology, Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy

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impinges negatively on a wide array of biological molecules and gene expression in cells. Usually, when oxidative stress occurs, compensatory antioxidant activity is established in order to restore redox balance ( Dalton et al. 1999 ). ROS are engaged in

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Ankita Das School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhimpur-Padanpur, Jatni, Khurda, Odisha, India
Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, India

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Arka Jyoti De School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhimpur-Padanpur, Jatni, Khurda, Odisha, India
Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, India

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Tanuja Mohanty School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhimpur-Padanpur, Jatni, Khurda, Odisha, India
Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, India

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Palok Aich School of Biological Sciences, National Institute of Science Education and Research (NISER), Bhimpur-Padanpur, Jatni, Khurda, Odisha, India
Homi Bhabha National Institute, Training School Complex, Anushaktinagar, Mumbai, India

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the ER, which causes the formation of ROS and alters the redox balance of the ER. Furthermore, by its direct interaction with PDI, the ER-specific isoform of the NADPH oxidase 4 protein (Nox4) is directly connected to ROS production. Therefore

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