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Teresa Vezza Servicio de Digestivo, Hospital Universitario Virgen de las Nieves, Granada, Spain

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Clara Luna-Marco Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain

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Susana Rovira-Llopis Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain

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Víctor M Víctor Service of Endocrinology and Nutrition, University Hospital Doctor Peset, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region (FISABIO), Valencia, Spain
Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
CIBERehd, University of Valencia, Valencia, Spain

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Introduction Type 2 diabetes (T2D), characterized by hyperglycaemia, is associated with increased generation of reactive oxygen species (ROS) and, thus, oxidative stress ( Apostolova et al. 2020 ). There are different endogenous sources of

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Biplab Kumar Dash Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Tatara, Kyotanabe, Kyoto, Japan

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Yasuomi Urano Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Tatara, Kyotanabe, Kyoto, Japan

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Yoshiro Saito Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

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Noriko Noguchi Systems Life Sciences Laboratory, Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University, Tatara, Kyotanabe, Kyoto, Japan

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oxidation phenomenon known as oxidative stress. Consistent oxidative stress leads to numerous disease manifestations characterized by non-specific posttranslational modifications and functional protein aggregation. The DJ-1 (also called the DJ-1/PfpI, ThiJ

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Mathieu Repellin LAGEPP UMR 5007, Univ Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France
PULSALYS SATT Lyon-Saint Etienne, Villeurbanne, France

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Hanäé Guerin LAGEPP UMR 5007, Univ Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France

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Giuseppina Catania LAGEPP UMR 5007, Univ Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France

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Giovanna Lollo LAGEPP UMR 5007, Univ Lyon, Université Claude Bernard Lyon 1, Villeurbanne, France

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to oxidative stress which is related to cellular damage and aging process, and is implicated in the development of various diseases such as neurodegenerative disorders, chronic diseases and cancers ( Hayes et al. 2020 , Sharifi-Rad et al. 2020

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Giulia Elda Valenti Department of Experimental Medicine, University of Genova, Italy

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Bruno Tasso Department of Pharmacy, University of Genova, Italy

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Nicola Traverso Department of Experimental Medicine, University of Genova, Italy

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Cinzia Domenicotti Department of Experimental Medicine, University of Genova, Italy

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Barbara Marengo Department of Experimental Medicine, University of Genova, Italy

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on the induction of oxidative stress through the administration of pro-oxidant chemotherapeutic drugs or ionizing radiation ( Pelicano et al. 2004 , Holley et al. 2014 ). Unfortunately, these approaches, after an initial success, lead to the

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Josh Thorley School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK

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Abrar Alhebshi School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK
Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, KSA

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Stephen J Bailey School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK

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Neil R W Martin School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK

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Nicolette C Bishop School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK

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Tom Clifford School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK

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.1016/J.BJ.2020.02.005 ) Ballmann C McGinnis G Peters B Slivka D Cuddy J Hailes W Dumke C Ruby B & Quindry J 2014 Exercise-induced oxidative stress and hypoxic exercise recovery . European Journal of Applied Physiology 114 725 – 733

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Yoshiro Saito Laboratory of Molecular Biology and Metabolism, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Miyagi, Japan

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Character and function Glutathione peroxidase 1 GPxl, GPXl KO mouse shows highly sensitive to oxidative stress Glutathione peroxidase 2 GPx2, GPX2 Protein levels are maintained under selenium deficiency Glutathione peroxidase 3

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Tania Medali Biological Adaptation and Ageing (B2A), CNRS UMR-8256/INSERM ERL U-1164, Biological Institute Paris-Seine, Sorbonne University, Paris, France

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Dominique Couchie Biological Adaptation and Ageing (B2A), CNRS UMR-8256/INSERM ERL U-1164, Biological Institute Paris-Seine, Sorbonne University, Paris, France

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Nathalie Mougenot Plateforme PECMV, UMS28 INSERM, Faculté de Médecine, Sorbonne University, Paris, France

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Maria Mihoc Plateforme PECMV, UMS28 INSERM, Faculté de Médecine, Sorbonne University, Paris, France

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Olaf Bergmann Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden CRTD, TU Dresden, Dresden, Germany

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Wouter Derks Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden CRTD, TU Dresden, Dresden, Germany

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Celio X Santos BHF Centre of Excellence King's College London, The James Black Centre, London, UK

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Bertrand Friguet Biological Adaptation and Ageing (B2A), CNRS UMR-8256/INSERM ERL U-1164, Biological Institute Paris-Seine, Sorbonne University, Paris, France

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Mustapha Rouis Biological Adaptation and Ageing (B2A), CNRS UMR-8256/INSERM ERL U-1164, Biological Institute Paris-Seine, Sorbonne University, Paris, France

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release and cell death ( Zhang et al. 2004 ). Moreover, Trx-2 improves endothelial cell function and reduces atherosclerotic lesions in the apolipoprotein E-deficient mouse model via reducing oxidative stress and increasing NO bioavailability ( Zhang et

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Heaji Lee Department of Food and Nutrition, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea

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Soo Jin Yang Department of Food and Nutrition, Seoul Women’s University, Seoul, Korea

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Yunsook Lim Department of Food and Nutrition, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea

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proteolysis and impaired protein synthesis, followed by muscle damage under hyperglycemic conditions ( Smith et al. 1989 , Lecker et al. 1999 ). Furthermore, changes in energy metabolism are linked to impaired insulin signaling, increased oxidative stress

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Mariapaola Nitti Department of Experimental Medicine, University of Genoa, Italy

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Jasmin Ortolan Department of Experimental Medicine, University of Genoa, Italy

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Anna Lisa Furfaro Department of Experimental Medicine, University of Genoa, Italy

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reduces the growth of non-small cell lung cancer (NSCLC) and prostate cancer, respectively ( Pu et al. 2017 , Yang et al. 2017 ), and we proved that miR494 favors neuroblastoma cell survival in oxidative stress condition by inducing HO-1 ( Piras et

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Imen Ghzaiel Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France
Lab-NAFS ‘Nutrition-Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia
Faculty of Sciences of Tunis, University Tunis-El Manar, Tunis, Tunisia

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Khouloud Sassi Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France

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Amira Zarrouk Lab-NAFS ‘Nutrition-Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia
Faculty of Medicine, University of Sousse, Sousse, Tunisia

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Shubhrima Ghosh School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, The University of Dublin, College Green, Dublin 2, Ireland

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Irundika H K Dias Aston Medical School, Aston University, Birmingham, UK

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Thomas Nury Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France

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Mohamed Ksila Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France
Department of Biology, Faculty of Sciences, University Tunis-El Manar, Loboratory of Neurophysiology, Cellular Physiopathology and Valorisation of BioMolecules, LR18ES03, Tunis, Tunisia

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Soukaina Essadek Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France
Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, Settat, Morocco

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Mounia Tahri Joutey Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France
Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, Settat, Morocco

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Fatiha Brahmi Laboratory Biomathématique, Biochimie, Biophysique et Scientométrie, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, Algeria

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Wafa Mihoubi Laboratoire de Biotechnologie Moléculaire des Eucaryotes, Centre de Biotechnologie de Sfax, Université de Sfax, Sfax, Tunisia

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Sandrine Rup-Jacques LCPMC-A2, ICPM, Department of Chemistry, University Lorraine, Metz Technopôle, Metz, France

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Mohammad Samadi LCPMC-A2, ICPM, Department of Chemistry, University Lorraine, Metz Technopôle, Metz, France

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Leila Rezig University of Carthage, National Institute of Applied Sciences and Technology, LR11ES26, LIP-MB ‘Laboratory of Protein Engineering and Bioactive Molecules’, Tunis, Tunisia
University of Carthage, High Institute of Food Industries, El Khadra City, Tunis, Tunisia

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Smail Meziane Institut Européen des Antioxydants, Neuves-Maisons, France

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Taoufik Ghrairi Department of Biology, Faculty of Sciences, University Tunis-El Manar, Loboratory of Neurophysiology, Cellular Physiopathology and Valorisation of BioMolecules, LR18ES03, Tunis, Tunisia

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Olfa Masmoudi-Kouki Department of Biology, Faculty of Sciences, University Tunis-El Manar, Loboratory of Neurophysiology, Cellular Physiopathology and Valorisation of BioMolecules, LR18ES03, Tunis, Tunisia

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Sonia Hammami Lab-NAFS ‘Nutrition-Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia

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Boubker Nasser Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, Settat, Morocco

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Mohamed Hammami Lab-NAFS ‘Nutrition-Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia

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Yuqin Wang Swansea University Medical School, Swansea, Wales, UK

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William J Griffiths Swansea University Medical School, Swansea, Wales, UK

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Anne Vejux Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France

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Gérard Lizard Team ‘Biochemistry of the Peroxisome, Inflammation and Lipid Metabolism’ EA7270/Inserm, University Bourgogne Franche-Comté, Dijon, France

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: 26976653), Nieman Pick disease type C (PMID: 29626102), and type B (PMID: 31009661), as well as in patients with severe forms of X-linked adrenoleukodystrophy (X-ALD, PMID: 300100) ( Nury et al. 2017 ). In vitro , 7KC induces oxidative stress, as well as

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