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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
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Department of Physiology, University of Valencia, INCLIVA, Valencia, Spain
CIBERehd, University of Valencia, Valencia, Spain
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Introduction Type 2 diabetes (T2D), characterized by hyperglycaemia, is associated with increased generation of reactive oxygen species (ROS) and, thus, oxidative stress ( Apostolova et al. 2020 ). There are different endogenous sources of
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oxidation phenomenon known as oxidative stress. Consistent oxidative stress leads to numerous disease manifestations characterized by non-specific posttranslational modifications and functional protein aggregation. The DJ-1 (also called the DJ-1/PfpI, ThiJ
PULSALYS SATT Lyon-Saint Etienne, Villeurbanne, France
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to oxidative stress which is related to cellular damage and aging process, and is implicated in the development of various diseases such as neurodegenerative disorders, chronic diseases and cancers ( Hayes et al. 2020 , Sharifi-Rad et al. 2020
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on the induction of oxidative stress through the administration of pro-oxidant chemotherapeutic drugs or ionizing radiation ( Pelicano et al. 2004 , Holley et al. 2014 ). Unfortunately, these approaches, after an initial success, lead to the
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Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, KSA
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.1016/J.BJ.2020.02.005 ) Ballmann C McGinnis G Peters B Slivka D Cuddy J Hailes W Dumke C Ruby B & Quindry J 2014 Exercise-induced oxidative stress and hypoxic exercise recovery . European Journal of Applied Physiology 114 725 – 733
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Character and function Glutathione peroxidase 1 GPxl, GPXl KO mouse shows highly sensitive to oxidative stress Glutathione peroxidase 2 GPx2, GPX2 Protein levels are maintained under selenium deficiency Glutathione peroxidase 3
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release and cell death ( Zhang et al. 2004 ). Moreover, Trx-2 improves endothelial cell function and reduces atherosclerotic lesions in the apolipoprotein E-deficient mouse model via reducing oxidative stress and increasing NO bioavailability ( Zhang et
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proteolysis and impaired protein synthesis, followed by muscle damage under hyperglycemic conditions ( Smith et al. 1989 , Lecker et al. 1999 ). Furthermore, changes in energy metabolism are linked to impaired insulin signaling, increased oxidative stress
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reduces the growth of non-small cell lung cancer (NSCLC) and prostate cancer, respectively ( Pu et al. 2017 , Yang et al. 2017 ), and we proved that miR494 favors neuroblastoma cell survival in oxidative stress condition by inducing HO-1 ( Piras et
Lab-NAFS ‘Nutrition-Functional Food & Vascular Health’, Faculty of Medicine, University of Monastir, Monastir, Tunisia
Faculty of Sciences of Tunis, University Tunis-El Manar, Tunis, Tunisia
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Faculty of Medicine, University of Sousse, Sousse, Tunisia
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Department of Biology, Faculty of Sciences, University Tunis-El Manar, Loboratory of Neurophysiology, Cellular Physiopathology and Valorisation of BioMolecules, LR18ES03, Tunis, Tunisia
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Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, Settat, Morocco
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Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences & Techniques, University Hassan I, Settat, Morocco
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University of Carthage, High Institute of Food Industries, El Khadra City, Tunis, Tunisia
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: 26976653), Nieman Pick disease type C (PMID: 29626102), and type B (PMID: 31009661), as well as in patients with severe forms of X-linked adrenoleukodystrophy (X-ALD, PMID: 300100) ( Nury et al. 2017 ). In vitro , 7KC induces oxidative stress, as well as