Print
Save
Email this link

Share Link

Copy this link, or click below to email it to a friend
Email this link
or copy the link directly:

https://rem.bioscientifica.com/search?f_0=author&q_0=Nicola+Traverso
The link was not copied. Your current browser may not support copying via this button.

Link copied successfully

Search Results

You are looking at 1 - 1 of 1 items for

Author: Nicola Traverso x

Clear All Modify Search

Glutathione in cancer progression and chemoresistance: an update

Giulia Elda Valenti

Giulia Elda Valenti Department of Experimental Medicine, University of Genova, Italy

Search for other papers by Giulia Elda Valenti in
Google Scholar
PubMed

Bruno Tasso

Bruno Tasso Department of Pharmacy, University of Genova, Italy

Search for other papers by Bruno Tasso in
Google Scholar
PubMed

Nicola Traverso

Nicola Traverso Department of Experimental Medicine, University of Genova, Italy

Search for other papers by Nicola Traverso in
Google Scholar
PubMed

Cinzia Domenicotti

Cinzia Domenicotti Department of Experimental Medicine, University of Genova, Italy

Search for other papers by Cinzia Domenicotti in
Google Scholar
PubMed

, and

Barbara Marengo

Barbara Marengo Department of Experimental Medicine, University of Genova, Italy

Search for other papers by Barbara Marengo in
Google Scholar
PubMed

Glutathione (GSH) is one of the most important components of the cellular antioxidant system, and it is able to exert several pleiotropic functions influencing cell growth, proliferation, adaptation and death. It has been demonstrated that changes in GSH levels underlie the pathogenesis of many human diseases, including cancer. In detail, although on one hand GSH homeostasis plays a protective role from the onset of cancer, on the other, it is involved in cancer progression and in therapy resistance. In this review, after a brief report on the physiological role of GSH, we have focused the attention on its role in cancer and refractoriness to anticancer therapy giving an update on the preclinical and clinical studies relied on the compounds targeting GSH system. Based on these considerations, a deeper knowledge of GSH-dependent network can be crucial to identify new strategies for preventing and/or curing cancer.