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Valeria Cordone V Cordone, University of Ferrara, Ferrara, 44121, Italy

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Anna Guiotto A Guiotto, North Carolina State University at Raleigh, Raleigh, United States

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Vivian Bucay V Bucay, Bucay Center for Dermatology and Aesthetics, San Antonio, United States

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Alessandra Pecorelli A Pecorelli, Animal Science Dept., North Carolina State University at Raleigh, Raleigh, United States

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Giuseppe Valacchi G Valacchi, NCSU, Kannapolis, 28081, United States

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Trichothiodystrophy (TTD) is a rare hereditary disease whose prominent feature is brittle hair. Additional clinical signs are physical and neurodevelopmental abnormalities and in about half of the cases hypersensitivity to UV radiation. Although the mutations involved in this condition have been characterized, the correlation between the molecular defects and the plethora of clinical symptoms is not well understood. Recently the presence of a redox unbalance in TTD has been suggested although not clear evidences have been reported on this aspect.

Therefore, in the present study, we evaluated the redox status of fibroblasts isolated from a TTD patient. In addition, to understand the ability of TTD cells to respond to oxidative insults, the cells were challenged with H2O2 and mitochondrial O2- and mitochondrial membrane potential were measured in different oxidative conditions. In addition, NRF2/BACH protein levels were also analysed in response to H2O2.

The results suggested an aberrant mitochondrial response to oxidative stimuli, an increased baseline oxidative stress status in TTD and an altered NRF2/BACH level.

This study emphasises that altered redox homeostasis might play a role in TTD pathogenesis and mitochondria functionality could represent an alternative therapeutic target for this condition to improve patients clinical features.

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