Alteration of Redox Homeostasis and Liver Diseases Special Collection

Liver diseases cause 2 million deaths per year worldwide, mostly attributed to cirrhosis and liver cancer. Viral hepatitis has been the leading etiology for liver diseases, but recently improved treatments and preventive strategies have changed the current clinical scenario. Indeed, metabolic alterations and alcohol intake, which are frequent and rising in several countries, have become key causal factors of liver disease.

Alterations of redox homeostasis are described in the development and progression of liver diseases, including viral hepatitis, alcoholic liver disease, metabolic-associated liver disease, cholestatic liver diseases, toxic and autoimmune hepatitis, as well as hepatic ischemia-reperfusion and hepatocellular carcinoma. A significant knowledge of how redox biology and redox-dependent pathways influence liver disease may lead to the use of feasible biomarkers and effective therapies in clinical practice. Nevertheless, there are no currently approved laboratory markers to detect or monitor the progression of hepatic conditions. Furthermore, despite promising in pre-clinical investigations, conventional antioxidants were demonstrated as not beneficial in human studies. Recent technological advances, especially in metabolomics, redox indicators, and pharmaceutical delivery strategies provide the means to expand our knowledge of mechanisms and ability of therapeutics, increasing our capacity to translate new understanding to improve human liver health.

This special collection aims to cover redox-dependent pathophysiological mechanisms related to liver diseases, using a translational approach which focuses both on markers for early diagnosis and on therapeutic targets.

The collection is edited by Associate Professor Francesco Bellanti (University of Foggia, Italy) whose research focuses on the study of mitochondria metabolism, redox balance and redox signalling applied to liver metabolism and pathophysiology, cell senescence, and stem cell physiology.

Collection Editor

We welcome submissions of all manuscript types, but are especially interested in original research in the area. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection page on the journal website. Manuscripts should be submitted via the submission site. If you would like to submit a manuscript and have any questions please email it to the editorial office at rem@bioscientifica.com.

Read the latest articles published in the special series:

Oxidative stress in non-alcoholic fatty liver disease (NAFLD): a reappraisal of the role in supporting inflammatory mechanisms
Salvatore Sutti and Emanuele Albano

Redox experimental medicine and liver regeneration
Francesco Bellanti, Gianluigi Vendamiale and Gaetano Serviddio

Triglyceride peroxidation progression in hepatocytes lipid droplets in non-alcoholic steatohepatitis
Kota Saito, Yuta Matsuoka, Masami Abe, Nao Kato, Kazushi Morimoto and Ken-ichi Yamada

Role of Oxidative Stress, Gut Microbiota and derived metabolites in the Etiology and progression of NAFLD
Ankita Das, Arka Jyoti De, Tanuja Mohanty and Palok Aich